Groups and projects

Movement disorders and sensorimotor plasticity

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Translational Neurotechnology

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We study higher-order cognitive functions at the level of individual neurons and their networks. Intelligent, goal-directed behavior is produced by the interaction of populations of neurons in the cognitive brain centers such as the prefrontal cortex, the parietal cortex and the basal ganglia. We develop and use technologies for recording from individual neurons directly in human subjects and combine these with a variety of state-of-the-art methods in animal models (fluorescent neuroimaging, large-scale extracellular recordings, optogenetics, and computational modelling).

More information at simonjacob.de

 

Brain structure and function in schizophrenia and obsessive-compulsive disorder

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Neurooncology and functional neuronavigation and -monitoring

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Morphometry in Multiple Sclerosis

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PainLabMunich

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Our research group investigates how the human brain generates pain. Understanding these processes provides basic insights into how the brain translates objective sensory information into a subjective experience. Beyond, such insights are crucial for harnessing these processes for the treatment of pain. Moreover, changes of these processes figure prominently in the susceptibility, development and maintenance of long-lasting pain in chronic pain disorders. Insights into the brain mechanisms of chronic pain can therefore help to develop biomarkers and novel treatment strategies for chronic pain. To achieve these goals, we use electroencephalography (EEG) and cutting-edge analysis techniques to investigate the role of neuronal oscillations, or brain rhythms, in the cerebral processing of pain. Moreover, we use non-invasive brain stimulation (transcranial alternating current stimulation, tACS) and neurofeedback to modulate neuronal oscillations and alleviate pain.

Please check our website PainLabMunich.de for more information.

 

MR physics

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Neuroenergetics of the human brain

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The human brain consumes around 20% of the energy produced by the body. While neuroscience research has immensely progressed in understanding the micro- and macroscopic architecture of the brain, the reason for its high energy demands is still a mystery. In my research group, we study how energy metabolism drives neural signaling and whether it is altered in neuropsychiatric disorders. At TUM, I have established simultaneous measurements of glucose, oxygen and neurotransmitter metabolism in the human brain combining quantitative PET, calibrated fMRI and edited MRS on an integrated PET/MR-scanner. We also use TMS to non-invasively modulate human brain activity.

Please check my webpage for current projects and open positions via: valentinriedl.de

 

Neuropsychiatry and Neuroimaging Lab

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The Neuropsychiatry and Neuroimaging Lab studies structure and physiology of the brain in healthy controls and patients with neurodevelopmental disorders, namely schizophrenia and preterm birth, via multimodal brain imaging. In particular, we focus on brain systems defined by coordinated blood and vascular properties, such as intrinsic brain networks, and how blood, vascular, para-vascular, and neuronal-metabolic properties link among each other, for example what are drivers of a directed flow in the para-vascular glymphatic system. The imaging methods used are mainly structural and functional MRI, extended for perfusion- and diffusion-based MRI as well as different PET techniques.

 

Analysis of functional connectivity dynamics from fMRI

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